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VU 0357017 hydrochloride

CAS No. 1135242-13-5

VU 0357017 hydrochloride( VU0357017, VU-0357017, VU 0357017, CID 25010775 )

Catalog No. M17152 CAS No. 1135242-13-5

VU 0357017 hydrochloride is highly selective M1 agonists act at an allosteric site to activate the receptor (EC50: 477 ± 172 nM; Pec50: 6.37 ± 0.15).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 97 In Stock
25MG 191 In Stock
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100MG 422 In Stock
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Biological Information

  • Product Name
    VU 0357017 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    VU 0357017 hydrochloride is highly selective M1 agonists act at an allosteric site to activate the receptor (EC50: 477 ± 172 nM; Pec50: 6.37 ± 0.15).
  • Description
    VU0357017, also known as CID 25010775, is a subtype-selective M1 muscarinic acetylcholine allosteric agonist.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Male Sprague?Dawley rats (380-420 g) were pretreated with scopolamine Dosage:1, 3, 10 mg/kg Administration:A single i.p.Result:Produced a significant reversal of the scopolamine-induced deficits at a dose of 10 mg/kg.
  • Synonyms
    VU0357017, VU-0357017, VU 0357017, CID 25010775
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    M1 mAChR
  • Research Area
    Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    1135242-13-5
  • Formula Weight
    369.89
  • Molecular Formula
    C18H28ClN3O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 33 mg/mL 89.22 mM
  • SMILES
    CCOC(=O)N1CCC(CC1)NCCNC(=O)c1ccccc1C.Cl
  • Chemical Name
    4-[[2-[(2-methylbenzoyl)amino]ethyl]amino]-1-piperidinecarboxylic acid ethyl ester, monohydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Digby GJ, et al. ACS Chem Neurosci. 2012 Dec 19;3(12):1025-36.
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